CKK-E12

• Description:

  CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Liposome

• Type:

  Oligonucleotides

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ckk-e12.html

• Concentration:

  10mM

• Purity:

  98.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)N1)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O

• Molecular Formula:

  C60H120N4O6

• Molecular Weight:

  993.62

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111 (15) :5753]. Proc Natl Acad Sci U S A. 2014;111 (11) :3955-3960. |[2]Oberli MA, Reichmuth AM, Dorkin JR, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017;17 (3) :1326-1335. |[3]Hatit MZC, et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat Nanotechnol. 2022 Mar;17 (3) :310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  No Development Reported

• CAS Number:

  [1432494-65-9]