Products for Research Use Only
RegisterLogin

Pactimibe (sulfate)

CAT: 0804-HY-100401A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-100401A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2].
CAS Number
608510-47-0
Product Name Alternative
CS-505
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H373
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pactimibe-sulfate.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 120 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)CC1=C(C)C2=C(N(CCCCCCCC)CC2)C(NC(C(C)(C)C)=O)=C1C.O=S(O)(O)=O.[1/2]
Molecular Formula
C25H40N2O3.1/2H2O4S
Molecular Weight
465.65
Precautions
H302, H315, H319, H335, H373
References & Citations
[1]Naoki Terasaka, et al. ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice. Atherosclerosis. 2007 Feb;190 (2) :239-47.|[2]Ken Kitayama, et al. Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe. Eur J Pharmacol. 2006 Jul 1;540 (1-3) :121-30.|[3]Yasunobu Yoshinaka, et al. A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice. Atherosclerosis. 2010 Nov;213 (1) :85-91.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
ACAT; ACAT1; ACAT2

Related Products

CatalogName
HY-100401-01Pactimibe
HY-116282J-01Dextran sulfate, low sulfate (MW 5000)
HY-116282P-01Dextran sulfate, high sulfate (MW 5000)
HY-116282M-01Dextran sulfate, low sulfate (MW 40000)
HY-16955A-01Plazomicin (sulfate)
HY-111355-01Cholesterol sulfate
HY-W001273Pramiracetam (sulfate)
HY-148375-01Abiraterone sulfate
HY-N0430A-01Coptisine (Sulfate)
HY-19806A-01Ceftolozane (sulfate)

Alternative Products

CatalogName
T62974-01Pactimibe sulfate
TRC-P156450-50MGPactimibe Sulfate (2:1)
GTR19196828-01Pactimibe
D3727-28Diphenyleneiodonium Sulfate (DPI Sulfate)
27428602-1gCapastat sulfate (Capreomycin sulfate)
sc-506292Potassium Sulfate (Sulfate of Potash)
90021020-1gCapreomycin sulfate (Capastat sulfate)
B8996-03Butacaine Sulfate (Butyn Sulfate)
505483-01DHEA Sulfate, Dihydrate (Dehydroepiandrosterone Sulfate)
MBS618330-01DHEA 3 Sulfate (Dehydroepiandrosterone Sulfate)

Popular Products