L-Canaline

• Description :

  L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects[1][2][3].

• CAS Number :

  [496-93-5]

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H312, H315, H318, H332, H335

• Target :

  Endogenous Metabolite; Parasite

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/l-canaline.html

• Purity :

  95.0

• Solubility :

  DMSO : 1 mg/mL (ultrasonic; warming)

• Smiles :

  N[C@@H](CCON)C(O)=O

• Molecular Formula :

  C4H10N2O3

• Molecular Weight :

  134.13

• Precautions :

  H302, H312, H315, H318, H332, H335

• References & Citations :

  [1]Bence AK, et al. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anticancer Drugs. 2002 Mar;13 (3) :313-20.|[2]Rosenthal GA. L-canaline: a potent antimetabolite and anti-cancer agent from leguminous plants. Life Sci. 1997;60 (19) :1635-41.|[3]Berger BJ. Antimalarial activities of aminooxy compounds. Antimicrob Agents Chemother. 2000 Sep;44 (9) :2540-2.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Plasmodium