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L-Canaline

CAT: 0804-HY-129476-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129476-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects[1][2][3].
CAS Number
496-93-5
UNSPSC
12352211
Hazard Statement
H302, H312, H315, H318, H332, H335
Target
Endogenous Metabolite; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/l-canaline.html
Purity
95.0
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
N[C@@H](CCON)C(O)=O
Molecular Formula
C4H10N2O3
Molecular Weight
134.13
Precautions
H302, H312, H315, H318, H332, H335
References & Citations
[1]Bence AK, et al. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anticancer Drugs. 2002 Mar;13 (3) :313-20.|[2]Rosenthal GA. L-canaline: a potent antimetabolite and anti-cancer agent from leguminous plants. Life Sci. 1997;60 (19) :1635-41.|[3]Berger BJ. Antimalarial activities of aminooxy compounds. Antimicrob Agents Chemother. 2000 Sep;44 (9) :2540-2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium

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