L-Canaline

• Description:

  L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H312, H315, H318, H332, H335

• Target:

  Endogenous Metabolite; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/l-canaline.html

• Purity:

  95.0

• Solubility:

  DMSO : 1 mg/mL (ultrasonic; warming)

• Smiles:

  N[C@@H](CCON)C(O)=O

• Molecular Formula:

  C4H10N2O3

• Molecular Weight:

  134.13

• Precautions:

  H302, H312, H315, H318, H332, H335

• References & Citations:

  [1]Bence AK, et al. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anticancer Drugs. 2002 Mar;13 (3) :313-20.|[2]Rosenthal GA. L-canaline: a potent antimetabolite and anti-cancer agent from leguminous plants. Life Sci. 1997;60 (19) :1635-41.|[3]Berger BJ. Antimalarial activities of aminooxy compounds. Antimicrob Agents Chemother. 2000 Sep;44 (9) :2540-2.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Plasmodium

• CAS Number:

  [496-93-5]