Melatonin-Tamoxifen Conjugate

CAT: 0804-HY-169382Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-169382Size:1 Each
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Description
Melatonin-Tamoxifen Conjugate (compound 16c) is an anticancer drug conjugate composed of Melatonin (HY-B0075) and Tamoxifen (HY-13757A), which is a potent antagonist of ERα (IC50=863 nM) . Melatonin-Tamoxifen Conjugate binds to MLT receptor (Ki=3.1 nM) and promotes β-arrestin (EC50=914 nM) and ERK activation (EC50=98 nM) in cells expressing hMT1 receptor. Melatonin-Tamoxifen Conjugate against several common cell lines MCF-7, MDA-MB-231, and HT-1080 with IC50s of 6.8 μM, 6.4 μM, and 1.7 μM, respectively.
UNSPSC
12352005
Target
Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/melatonin-tamoxifen-conjugate.html
Smiles
O=C(NCCCOC1=CC2=C(NC=C2CCNC(C)=O)C=C1)CCCCCCN(CCOC3=CC=C(/C(C4=CC=CC=C4)=C(C5=CC=CC=C5)/CC)C=C3)C
Molecular Formula
C47H58N4O4
Molecular Weight
742.99
References & Citations
[1]Marzouk MA, et al. Cancer Cells Show Higher Sensitivity to Melatonin-Tamoxifen Drug Conjugates than to Combination of Melatonin and Tamoxifen. ACS Omega. 2024 Nov 18;9 (48) :47857-47871.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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