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Tamoxifen-​d5

CAT: 0804-HY-13757ASSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13757ASSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].
CAS Number
157698-32-3
Product Name Alternative
ICI 47699-​d5; (Z) -Tamoxifen-​d5; trans-Tamoxifen-​d5
UNSPSC
12352005
Hazard Statement
H302, H350, H360, H410
Target
Apoptosis; Autophagy; Estrogen Receptor/ERR; HSP; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.99
Solubility
DMSO : 83.33mg/mL (ultrasonic)
Smiles
[2H]C([2H])([2H])C([2H])([2H])/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3
Molecular Formula
C26H24D5NO
Molecular Weight
376.55
Precautions
H302, H350, H360, H410
References & Citations
[1]Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339 (22) :1609-18.|[2]Zhao R, et al. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. PLoS One. 2010 Apr 1;5 (4) :e9934.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Estrogen receptor; HSP90

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