Kaempferol

• Description:

  Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4].

• Product Name Alternative:

  Kempferol; Robigenin

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H341

• Target:

  Apoptosis; Autophagy; Endogenous Metabolite; Estrogen Receptor/ERR; HIV; Mitophagy; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Kaempferol.html

• Purity:

  99.92

• Solubility:

  DMSO : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  OC1=C2C(OC(C3=CC=C(O)C=C3)=C(O)C2=O)=CC(O)=C1

• Molecular Formula:

  C15H10O6

• Molecular Weight:

  286.24

• Precautions:

  H301, H341

• References & Citations:

  [1]Luo H, et al. Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability. Int J Nanomedicine. 2012; 7: 3951-3959.|[2]Luo H, et al. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011 September 15; 128 (2) : 513-519.|[3]An M, et al. Protective effects of Kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. Anat Cell Biol. 2015 Dec;48 (4) :235-43.|[4]Shin D, et al. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015 Dec 16;16 (12) :29980-95.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 1

• Isoform:

  ERα; Human Endogenous Metabolite

• CAS Number:

  520-18-3