TA-01

TA-01

• CAS Number: 1784751-18-3
• UNSPSC Description: TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 acts as a cardiogenic inhibitor.
• Target Antigen: Autophagy; Casein Kinase; p38 MAPK
• Type: Reference compound
• Related Pathways: Autophagy;Cell Cycle/DNA Damage;MAPK/ERK Pathway;Stem Cell/Wnt
• Applications: COVID-19-anti-virus
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/TA-01.html
• Purity: 99.86
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: FC(C=C1)=CC=C1C2=C(C3=CC=NC=C3)NC(C4=C(F)C=CC=C4F)=N2
• Molecular Weight: 351.32
• References & Citations: [1]Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported