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Caf1-IN-1

CAT: 0804-HY-158970-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-158970-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Caf1-IN-1 (Compound 8j) is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly (A) -specific ribonuclease (PARN) with IC50 of 23.9 µM[1].
CAS Number
1807775-88-7
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/caf1-in-1.html
Purity
99.44
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N(CCCN(C)C)C(N1O)=O)N=CN2CCC3=CC=CC=C3
Molecular Formula
C18H23N5O3
Molecular Weight
357.41
References & Citations
[1]Jadhav GP, et al., Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly (A) -selective ribonuclease Caf1. Bioorg Med Chem Lett. 2015 Oct 1;25 (19) :4219-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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