Dioscin

Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity[1][2][3][4][5][6].

19057-60-4

Collettiside III; CCRIS 4123

12352005

H315, H319

Apoptosis; Autophagy

Natural Products

Apoptosis; Autophagy

Cancer-Kinase/protease

Cancer; Cardiovascular Disease

https://www.medchemexpress.com/Dioscin.html

99.95

DMSO : ≥ 100 mg/mL

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C45H72O16

869.04

H315, H319

[1]Chen J, et al. Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34 (1) :125-30.|[2]Qu X, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014 Jan 10;443 (2) :658-65.|[3]Qin J, et al. Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg) . 2014 Jan;64 (1) :47-52.|[4]Zhao X, et al. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. Molecules. 2016 Jun 4;21 (6) :730.|[5]Xu T, et al. A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats. Food Chem Toxicol. 2012 May;50 (5) :1279-87.|[6]Tao X, et al. Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis. Transplantation. 2014 Sep 27;98 (6) :604-11.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

Natural Products