Kukoamine B (Standard)

CAT: 0804-HY-N2393RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N2393RSize:1 Each
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Description
Kukoamine B (Standard) is the analytical standard of Kukoamine B. This product is intended for research and analytical applications. Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with Kd values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis[1][2][3][4].
CAS Number
[164991-67-7]
UNSPSC
12352005
Target
Akt; Apoptosis; DNA/RNA Synthesis; MAPKAPK2 (MK2) ; MMP; p38 MAPK; PI3K; Reference Standards; ROS Kinase
Type
Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kukoamine-b-standard.html
Smiles
O=C(N(CCCN)CCCCNCCCNC(CCC1=CC=C(O)C(O)=C1)=O)CCC2=CC=C(O)C(O)=C2
Molecular Formula
C28H42N4O6
Molecular Weight
530.66
References & Citations
[1]Li YY, et al. A Metabolomics Approach to Investigate Kukoamine B-A Potent Natural Product With Anti-diabetic Properties. Front Pharmacol. 2019 Jan 22;9:1575.|[2]Hu XL, et al. Neuroprotective effects of Kukoamine B against hydrogen peroxide-induced apoptosis and potential mechanisms in SH-SY5Y cells. Environ Toxicol Pharmacol. 2015 Jul;40 (1) :230-40. |[3]Park E, et al. Anti-Osteoporotic Effects of Kukoamine B Isolated from Lycii Radicis Cortex Extract on Osteoblast and Osteoclast Cells and Ovariectomized Osteoporosis Model Mice. Int J Mol Sci. 2019 Jun 6;20 (11) :2784. |[4]Liu X, et al. Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment. Br J Pharmacol. 2011 Mar;162 (6) :1274-90.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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