Kukoamine A

• Description :

  Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].

• UNSPSC :

  12352005

• Target :

  Parasite

• Type :

  Natural Products

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/kukoamine-a.html

• Purity :

  99.88

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(NCCCNCCCCNCCCNC(CCC1=CC=C(O)C(O)=C1)=O)CCC2=CC=C(O)C(O)=C2

• Molecular Formula :

  C28H42N4O6

• Molecular Weight :

  530.66

• References & Citations :

  [1]Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 (Pt 2) :371-5.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Trypanosoma

• CAS Number :

  [75288-96-9]