Kukoamine A

• UNSPSC Description:

  Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].

• Target Antigen:

  Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/kukoamine-a.html

• Purity:

  99.86

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCCNCCCCNCCCNC(CCC1=CC=C(O)C(O)=C1)=O)CCC2=CC=C(O)C(O)=C2

• Molecular Weight:

  530.66

• References & Citations:

  [1]Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 ( Pt 2):371-5.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  75288-96-9