Dithiodipropionic acid

• Description :

  Dithiodipropionic acid can interact with CPUL1 (HY-151802) (a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs) . CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dithiodipropionic-acid.html

• Concentration :

  10mM

• Purity :

  99.0

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(O)CCSSCCC(O)=O

• Molecular Formula :

  C6H10O4S2

• Molecular Weight :

  210.26

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1119-62-6]