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MS48107

CAT: 0804-HY-134494-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134494-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68) . MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cross the blood-brain barrier (BBB) in mice[1].
CAS Number
2375070-79-2
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
GPR68
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ms48107.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OCC1=CC=CC(F)=C1C2=NC(N)=NC(NCC3=CC=C(OC4=CC=CC=C4)C=C3)=N2
Molecular Formula
C23H20FN5O2
Molecular Weight
417.44
Precautions
H315, H319, H320
References & Citations
[1]Xufen Yu, et al. Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68) . J Med Chem. 2019 Aug 22;62 (16) :7557-7574.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor

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