Inakalant

CAT: 0804-HY-14924-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-14924-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Inakalant is an atrial specific potassium channel blocker with antiarrhythmic activity. Inakalant works by selectively blocking potassium channels in heart cells, thereby prolongs the action potential duration (APD) of cardiomyocytes and increases the effective refractory period of the atria and ventricles, which helps to terminate and prevent the occurrence of arrhythmias such as atrial fibrillation (AF) . Inakalant can be used in the study of arrhythmia and cardiac electrophysiology[1].

CAS Number

335619-18-6

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/inakalant.html

Smiles

N#CC(C=C1)=CC=C1OC[C@@H](O)CN2CC3OC(CN(C3)CCNC(OC(C)(C)C)=O)C2

Molecular Formula

C23H34N4O5

Molecular Weight

446.54

Precautions

P261-P280-P302+P352

References & Citations

[1]Edvardsson N, et al. Inverse correlation between the atrial fibrillatory rate and the ventricular repolarization time: observations at baseline and after an intravenous infusion of a combined potassium and sodium current blocker[J]. Annals of Noninvasive Electrocardiology, 2016, 21 (3) : 236-245.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Inakalant

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