Solanidine

• Description:

  Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  MDM-2/p53; RAD51

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/solanidine.html

• Purity:

  99.90

• Solubility:

  Ethanol : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@@]5([H])[C@H](C)[C@@]6([H])CC[C@H](C)CN6[C@]([H])5C[C@@]24[H]

• Molecular Formula:

  C27H43NO

• Molecular Weight:

  397.64

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhang ZD, et al. Synthesis of Demissidine and Solanidine.Org Lett. 2016 Jun 17;18 (12) :3038-40.|[2]Friedman M, et al. Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. Food Chem Toxicol. 2003 Jan;41 (1) :61-71.|[3]Sherapura A, et al. Steroidal alkaloid solanidine impedes hypoxia-driven ATM phosphorylation to switch on anti-angiogenesis in lung adenocarcinoma. Phytomedicine. 2023 Oct;119:154981.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [80-78-4]