Solanidine

CAT: 0804-HY-N7271-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N7271-01Size:1 mg
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Description
Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice[1][2][3].
CAS Number
[80-78-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MDM-2/p53; RAD51
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/solanidine.html
Purity
99.90
Solubility
Ethanol : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@@]5([H])[C@H](C)[C@@]6([H])CC[C@H](C)CN6[C@]([H])5C[C@@]24[H]
Molecular Formula
C27H43NO
Molecular Weight
397.64
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang ZD, et al. Synthesis of Demissidine and Solanidine.Org Lett. 2016 Jun 17;18 (12) :3038-40.|[2]Friedman M, et al. Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. Food Chem Toxicol. 2003 Jan;41 (1) :61-71.|[3]Sherapura A, et al. Steroidal alkaloid solanidine impedes hypoxia-driven ATM phosphorylation to switch on anti-angiogenesis in lung adenocarcinoma. Phytomedicine. 2023 Oct;119:154981.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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