(S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline

• UNSPSC Description:

  (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline is a connector for PROTAC, which can be used to synthesize (R)-NX-2127 (HY-153220A) and is utilized in research within the field of malignant tumors[1].

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-4-1-pyrrolidin-3-ylmethyl-piperidin-4-yl-aniline.html

• Smiles:

  NC(C=C1)=CC=C1C(CC2)CCN2C[C@@H]3CNCC3

• Molecular Weight:

  259.39

• References & Citations:

  [1]Daniel W Robbins, et al. Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. J Med Chem. 2024 Feb 22;67(4):2321-2336.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported