(R)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline

• UNSPSC Description:

  (R)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline is a linker for NX-2127 (HY-153220A)[1].

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/r-4-1-pyrrolidin-3-ylmethyl-piperidin-4-yl-aniline.html

• Smiles:

  NC(C=C1)=CC=C1C(CC2)CCN2C[C@H]3CNCC3

• Molecular Weight:

  259.39

• References & Citations:

  [1]Robbins D W, et al. Discovery and preclinical pharmacology of NX-2127, an orally bioavailable degrader of Bruton’s tyrosine kinase with immunomodulatory activity for the treatment of patients with B cell malignancies[J]. Journal of Medicinal Chemistry, 2024, 67(4): 2321-2336.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported