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Dimaprit (dihydrochloride)

CAT: 0804-HY-B1478-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1478-01Size:25 mg
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Description
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion[1][2].
CAS Number
23256-33-9
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Histamine Receptor; NO Synthase
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/dimaprit-dihydrochloride.html
Purity
99.91
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC(SCCCN(C)C)=N.[H]Cl.[H]Cl
Molecular Formula
C6H17Cl2N3S
Molecular Weight
234.19
Precautions
H315, H319, H335
References & Citations
[1]Parsons ME, et, al. Dimaprit - (S-[3- (N, N-dimethylamino) prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7 (1) : 31-7.|[2]Paquay JB, et, al. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br J Pharmacol. 1999 May; 127 (2) : 331-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H2 Receptor; nNOS

Chemical Information

Carbamimidothioic acid, 3-(dimethylamino)propyl ester, hydrochloride (1:2)
CAS Number23256-33-9
PubChem CID24871266
IUPAC Name3-(dimethylamino)propyl carbamimidothioate;hydrochloride
Molecular FormulaC6H16ClN3S
Molecular Weight197.73
Topological Polar Surface Area78.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count11
Formal Charge0
Complexity103
SMILES
CN(C)CCCSC(=N)N.Cl
InChI
InChI=1S/C6H15N3S.ClH/c1-9(2)4-3-5-10-6(7)8;/h3-5H2,1-2H3,(H3,7,8);1H
InChIKey
XFELLTMDCGRCBW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Carbamimidothioic acid, 3-(dimethylamino)propyl ester, hydrochloride (1:2)
CAS: 23256-33-9
CID: 24871266
Formula: C6H16ClN3S
MW: 197.73
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight197.73
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass197.0753464
Monoisotopic Mass197.0753464
Topological Polar Surface Area78.4 Ų
Heavy Atom Count11
Formal Charge0
Complexity103
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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