Poly (I) .Poly (C), HMW

CAT: 0793-15-1012-2Size: 2 mgDry Ice: NoHazardous: No
CAT#:0793-15-1012-2Size:2 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MW: High molecular weight (>1.5kb) . Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene-I (RIG-I), all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I:C) - induces pro-inflammatory TNF-alpha and antiviral IFN-beta, but can also enhance the expression of pro-apoptotic proteins. Recently, poly (I:C) -induced cell death recently gained considerable attention as a tool to study the 'Ripoptosome' or 'Necrosome' complex, a novel intracellular signaling complex, thought to induce regulated necrosis, also called 'Necroptosis'.
Product Name Alternative
Polyinosinic-polycytidylic acid, potassium salt (poly (I:C) )
Applications
Functional Assay
Purification
Purity:>=99%
Components
Liquid (1 mg/ml)
Storage Conditions
Store the product at 4°C for short term and at -20°C for long-term storage. The product is stable for 2 years at -20°C.

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