Human CFD Protein, hFc Tag

CAT: 0793-32-18294-100Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0793-32-18294-100Size:100 µg

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Description

Description :Recombinant Human CFD Protein with C-terminal human Fc tagBackground : This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. Molecular Characterization: mass of 50.5 kDa after removal of the signal peptide. The apparent molecular mass of CFD-hFc is approximately 55-70 kDa due to glycosylation.Tag :C-Human Fc Tag

Product Name Alternative

ADIPSIN; ADN; DF; PFD

UniProt

P00746

Host

HEK293

Target Antigen

CFD

Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.

UniProtKB · P00746

Complement factor D

CFAD_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P00746
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CFD
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.4.21.46
Processing: Precursor
Secondary accessions: B4DV76, Q5U5S1, Q86VJ5, Q8N4E0, Q8WZB4

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Complement alternate pathwayImmunityInnate immunity

Disease

Disease variant

PTM

Disulfide bondZymogen

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

Domain

Signal

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