RegisterLogin

GNMT Human, Active

CAT: 0793-32-6768-2Size: 2 µgDry Ice: NoHazardous: No
CAT#:0793-32-6768-2Size:2 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Source: Escherichia Coli.Sterile filtered colorless solution.GNMT is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine with glycine to S-adenosyl-L-homocysteine and sarcosine. GNMT is located in the cytoplasm and acts as a homotetramer. Defects in the GNMT gene causes of GNMT deficiency (hypermethioninemia) . GNMT affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and is involved in the detoxification pathway in liver cells. GNMT expression is diminished in human hepatocellular carcinoma (HCC) . GNMT catalyzes the methylation of glycine by using s- adenosylmethionine (adomet) to form n-methylglycine (sarcosine) with the concomitant production of s-adenosylhomocysteine (adohcy) . GNMT plays an essential role in the regulation of tissue concentration of adomet and of metabolism of methionine.GNMT Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-295 a.a) and having a molecular mass of 34.9kDa.GNMT is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Name Alternative
Glycine N-methyltransferase, GNMT, Glycine N-Methyltransferase, EC 2.1.1.20Epididymis Secretory Sperm Binding Protein Li 182mP, HEL-S-182mP.
Applications
Functional Assay
Purification
Greater than 95.0% as determined by SDS-PAGE.
Components
GNMT protein solution (1mg/mL) containing 20 mM Tris-HCl buffer (pH 8.0) and 20% glycerol.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.
Applications Notes
Specific activity is > 100 nmol/min/mg, and is defined as the amount of enzyme that transfer 1.0 nmole of methyl group per minute at 37C.
Amino Acids
MGSSHHHHHH SSGLVPRGSH MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK FRLSYYPHCL ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD.

Related Products

CatalogName
32-2379-50GNMT Recombinant Protein
32-13340-10NME3 Human, Active
32-13182-2CSTB Human, Active
32-13269-5IMPAD1 Human, Active
32-13269-1IMPAD1 Human, Active
32-6702-10CNDP1 Human, Active
32-6731-2DUSP18 Human, Active
32-6733-2ECHS1 Human, Active
32-6662-5ALDOC Human, Active
32-6753-10GAPDH Human, Active

Alternative Products

CatalogName
OM299911-01GNMT Human, Active
PROTQ14749-1GNMT Human, Glycine N-Methyltransferase Human Recombinant Protein , Active
enz-1059GNMT Active
OM299949-01GNMT Human
MBS8213466-01GNMT siRNA (Human)
22341051GNMT Adenovirus (Human)
HY-P70835-01GNMT, Human (His)
MBS7612927-01Recombinant Human GNMT
abx902232-01Human GNMT siRNA
32627-05111Human GNMT Antibody

Popular Products