Eotaxin 3 Recombinant Protein

Source : Escherichia Coli. Eotaxin-3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 72 amino acids (24-94 a.a.) and having a total molecular mass of 8.5kDa. Eotaxin-3 is purified by proprietary chromatographic techniques. Eotaxin-3 (CCL26) is a small cytokine that belongs to the CC chemokine family also known as TARC (thymus and activation regulated chemokine) . CCL26 is major eotaxin produced and released by alveolar epithelial cells which is involved in autoregulation of CCR3 receptors and other eotaxins. Eotaxin-3 is involved in immunoregulatory and inflammatory processes. Eotaxin-3 specifically binds and stimulates chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26 exhibits chemotactic activity for normal peripheral blood eosinophils and basophils. Eotaxin-3 may play a part in the eosinophil accumulation in atopic diseases. Eotaxin-3 is overexpressed in eosinophilic esophagitis, and the expression level correlates with disease severity. Eotaxin-3 is expressed constitutively in thymus, but only briefly in phytohemagglutinin-stimulated peripheral blood mononuclear cells. CCL26 is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7.

C-C motif chemokine 26||Small-inducible cytokine A26||Eotaxin-3||Macrophage inflammatory protein 4-alpha||MIP-4-alpha||Thymic stroma chemokine-1||TSC-1||CC chemokine IMAC||CCL26||SCYA26||IMAC||MIP-4a||MGC126714||MIP-4alpha.

Greater than 90.0% as determined by SDS-PAGE.

The Eotaxin-3 solution contains Phosphate Buffered Saline pH7.4 and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.