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Polyclonal Antibody to TFE3

CAT: 0793-35-1683-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-35-1683-50Size:50 μL
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Description
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5') . Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. Clark J., Lu Y.-J., Sidhar S.K., Parker C., Gill S. Oncogene 15:2233-2239 (1997) Weterman M.A.J., Wilbrink M., Proc. Natl. Acad. Sci. U.S.A. 93:15294-15298 (1996)
Product Name Alternative
BHLHE33|| TFEA|| RCCP2
Gene Name
TFE3
Gene ID
7030
UniProt
P19532
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.303~307 (L-D-V-Y-S) derived from Human TFE3.
Target Antigen
TFE3
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 70kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG

UniProtKB · P19532

Transcription factor E3

TFE3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19532
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TFE3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8MZL6, Q5JU74, Q92757, Q92758, Q99964
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Biological process

Adaptive immunityImmunityTranscriptionTranscription regulation

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

CytoplasmLysosomeMembraneNucleus

Disease

Disease variantIntellectual disabilityProto-oncogene

PTM

Isopeptide bondMethylationPhosphoproteinUbl conjugation

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