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Polyclonal Antibody to Src (Ab-529)

CAT: 0793-35-1510-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0793-35-1510-100Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme.
Product Name Alternative
C-SRC|| SRC1
Gene Name
SRC
Gene ID
6714
UniProt
P12931
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa. 527~531 (P-Q-Y-Q-P) derived from Human Src.
Target Antigen
Src (Ab-529)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 60kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG

UniProtKB · P12931

Proto-oncogene tyrosine-protein kinase Src

SRC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P12931
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SRC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.2
Processing
—
Secondary accessions
E1P5V4, Q76P87, Q86VB9, Q9H5A8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell adhesionCell cycleHost-virus interactionImmunity

Cellular component

Cell junctionCell membraneCytoplasmCytoskeletonMembraneMitochondrionMitochondrion inner membraneNucleus

Disease

Disease variantProto-oncogene

Molecular function

KinaseTransferaseTyrosine-protein kinase

PTM

LipoproteinMyristatePhosphoproteinUbl conjugation

Domain

SH2 domainSH3 domain

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