Polyclonal Antibody to eIF2beta (phospho-Ser2)

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CAT#:0793-35-1309-100Size:100 µL

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Description

EIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Structure of the beta subunit of translational initiation factor eIF-2. The DNA sequence and comparative analysis of human chromosome 20. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) .

Product Name Alternative

EIF2S2|| EIF2|| EIF2B

Gene Name

EIF2S2

Gene ID

8894

UniProt

P20042

Host

Rabbit

Reactivity

Rat, Mouse, Human

Immunogen

Peptide sequence around phosphorylation site of serine 2 (M-S (p) -G-D-E) derived from Human eIF2 beta.

Target Antigen

EIF2 Beta (phospho-Ser2)

Clonality

Polyclonal

Applications

Format

Purified

Components

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Applications Notes

Predicted MW: 38kd, Western blotting: 1:500~1:1000

Isotype

Rabbit IgG

UniProtKB · P20042

Eukaryotic translation initiation factor 2 subunit 2

IF2B_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P20042
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: EIF2S2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q9BVU0, Q9UJE4

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Cellular component

Cytoplasm

Biological process

Host-virus interactionProtein biosynthesis

Molecular function

Initiation factor

Ligand

Metal-bindingZinc

Domain

Zinc-finger

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Alternative Products

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MBS9408413-01	eIF2beta (phospho-Ser2) Antibody
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MBS9512034-01	eIF2beta Rabbit Polyclonal Antibody
TMAC-02482-01	Anti-Phospho-MAX (Ser2) Polyclonal Antibody
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APRab04979-01	Max (phospho Ser2) Rabbit Polyclonal Antibody
C11512	eIF2β (phospho-Ser2) Polyclonal Conjugated Antibody