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Anti-HLA-E PE (Clone : 3D12)

CAT: 0793-30-2521-0.1Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0793-30-2521-0.1Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HLA-E (Human Leukocyte Antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells) .Specificity : The mouse monoclonal antibody 3D12 (also known as 3D12HLA-E) recognizes native extracellular part of HLA-E, an ubiquitously expressed non-classical MHC class I molecule, as well as free HLA-E.
Product Name Alternative
HLA class I histocompatibility antigen, alpha chain E, MHC class I antigen E, major histocompatibility complex, class I, E
Gene Name
HLA-E
Gene ID
3133
Reactivity
Human
Target Antigen
HLA-E
Clonality
Monoclonal
Clone
3D12
Applications
FACS
Purification
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Components
0.1 mg/mLFormulation : Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Storage Conditions
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Isotype
Mouse IgG1
Conjugate
PE