Anti-HLA-E [3D12], Rabbit IgG, kappa

Anti-HLA-E [3D12], Rabbit IgG, kappa

• Gene Name: [HLA-E]
• NCBI Gene ID: 3133
• Reactivity: Human
• Storage Conditions: Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.
• Specificity: This antibody binds an extracellular epitope on the human HLA-E, a member of human leukocyte antigen family. This antibody is capable of reacting with free HLA-E heavy chain as well as heavy chain associated with b2-microglobulin and peptide. This antibody is reported to cross react with HLA-B and HLA-C but not with HLA-A, HLA-F or HLA-G. The human HLA-E is a non-classical MHC class 1B molecule involved in immune self-nonself discrimination. HLA-E plays a very important role in cell recognition by NK cells. Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self.
• Other Gene Names: [HLA-E; HLA-E; MHC; QA1; EA1.2; EA2.1; HLA-6.2; HLA-6.2; HLAE]
• Short Name: [HLA-E]
• Other Product Names: [HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC class I antigen E; lymphocyte antigen; major histocompatibility complex, class I, E; MHC class I antigen E]
• NCBI GI Number: 62912479
• NCBI Accession Number: NP_005507.3
• NCBI GB Accession Number: NM_005516.5
• Uniprot Accession Number: P13747