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Polyclonal antibody to FLIP

CAT: 0793-20-1065-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-20-1065-50Size:50 μL
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Description
This antibody recognizes FLIP long and short, isoforms that contain the peptide immunogen sequence (DRKAVETHLLRNPHLVSD) . Human FLIP is a 480 amino acid protein which contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by death receptors.However, the functions of FLIP remain to be fully elucidated and there is some evidence FLIP may also act as an activator of caspase-8/-10 in certain cases, thereby taking on an apoptosis promoting role.Cell death signals are transduced by death domain (DD) - containing adapter molecules and members of the caspase (ICE/CED-3) protease family. Most if not all, forms of apoptosis involve activation of the caspases. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the caspase family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7.
Product Name Alternative
CASH|| CASP8AP1||CLARP||MRIT
Gene Name
CFLAR
Gene ID
8837
UniProt
O15519
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptideof human FLIP (amino acids 75-92 DRKAVETHLLRNPHLVS) was used as immunogen for this antibody
Target Antigen
FLIP
Clonality
Polyclonal
Applications
IP, IHC, WB
Format
Sera
Components
50 μl sera
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
WB: 1:1000-1:2000, IHC (paraffin) : 1:1000-1:5000, IHC (frozen) : Users should optimize, IP: 1:50-1:200
Isotype
Rabbit IgG

UniProtKB · O15519

CASP8 and FADD-like apoptosis regulator

CFLAR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15519
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CFLAR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DJE0, B7Z9F9, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q53TS6, Q54AF1, Q96TE4, Q9UEW1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisHost-virus interaction

Domain

Repeat

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