Products for Research Use Only
RegisterLogin

Polyclonal antibody to BFAR (BAR)

CAT: 0793-20-1020-50Size: 50 μLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0793-20-1020-50Size:50 μL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BAR (bifunctional apoptosis regulator) is a multidomain protein that was originally identified as an inhibitor of Bax-induced apoptosis. BAR is in anchored in intracellular membranes and is thought to be a scaffold protein that may bridge components of both extrinsic and intrinsic apoptosis pathways through its antiapoptotic domains: 1. BAR contains a DED (death effector domain) -like protein interaction domain that suppresses death receptor apoptosis signaling pathways.BAR is highly expressed in the brain and expression patterns as well as functional data with neuronal cell lines suggest that BAR is involved in regulating neuronal survival. Additionally, subcellular localization studies indicate that BAR predominantly localizes to the endoplasmic reticulum (ER), irrespective of cell type. Bcl-2 family proteins also localize to the ER. There is important crosstalk between the ER and mitochondria in the execution of cell death. It is thought that both BAR and Bcl-2 proteins play a role in regulating cell death/apoptosis induced by ER stress. Dysregulation of ER homeostasis and apoptosis is thought to be involved in the pathogenesis of some human neuronal diseases, including Alzheimers, Parkinsons, polyglutamine diseases, nueronal storage diseases, prion dieases, as well as acute neurodegeration from brain trauma. Since BAR is normally widely expressed in the brain, it may have a cytoprotective function in helping neurons to survive for the entire lifetime of the organism by playing a central role in inhibiting ER initiated apoptosis.
Product Name Alternative
BFAR||BAR||RNF47
Gene Name
BFAR
Gene ID
51283
UniProt
Q9NZS9
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide of BFAR (BAR) protein (amino acids 3-21 EPQKSYVNTMDLERDEPLK) was used as the immunogen for this antibody
Target Antigen
BFAR (BAR)
Clonality
Polyclonal
Applications
IP, IHC, WB
Format
Sera
Components
50 μl sera
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
WB: 1:1000-1:2000, IHC (paraffin) : 1:1000-1:5000, IHC (frozen) : Users should optimize, IP: 1:50-1:200
Isotype
Rabbit IgG

UniProtKB · Q9NZS9

Bifunctional apoptosis regulator

BFAR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NZS9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BFAR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
A8K4Z9, B4DUT0, D3DUG8
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

Endoplasmic reticulumMembrane

PTM

GlycoproteinUbl conjugation

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Molecular function

Transferase

Domain

TransmembraneTransmembrane helixZinc-finger

Related Products

CatalogName
12-8142-1.0Anti-Barbiturate (BAR-8834)
32-8732-10Recombinant Streptomyces hygroscopicus Phosphinothricin N-acetyltransferase/Bar
32-8732-50Recombinant Streptomyces hygroscopicus Phosphinothricin N-acetyltransferase/Bar
30-1356-0.1Anti-CtBP1 / BARS Polyclonal Antibody
11-8032-25Polyclonal Antibody to GPR35
39-2164-100Polyclonal Antibody to VWF
35-1862-50Polyclonal Antibody to PSMA
35-1860-100Polyclonal Antibody to FHL2
35-1858-50Polyclonal Antibody to HIF2A
35-1838-100Polyclonal Antibody to SCF

Alternative Products

CatalogName
MBS668548-01Polyclonal Antibody to BFAR (BAR)
A10479Anti-BFAR (BAR) Antibody
APR02648GPolyclonal BAR / BFAR Antibody (C-Terminus)
MBS2540977-01BFAR Polyclonal Antibody
APR06603GPolyclonal BFAR Antibody
NB100-56093SSRabbit Polyclonal BFAR Antibody
MBS9466490-01BFAR Rabbit Polyclonal Antibody
A54543-050Bar Polyclonal Antibody
243767BFAR (bifunctional Apoptosis Regulator, BAR, RNF47)
MBS6012942-01BFAR, NT (BFAR, BAR, RNF47, Bifunctional apoptosis regulator, RING finger protein 47)

Popular Products