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Phospho-mTOR (Ser2448) (Clone: E11) rabbit mAb

CAT: 0793-12-4295-20Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0793-12-4295-20Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MTOR, mammalian target of rapamycin, is a Serine/Threonine protein kinase (1-2) that functions as an amino acid and ATP sensor to balance cell growth and nutrient availability (3-4) . When sufficient nutrients are available, mTOR transmits a positive signal to p70 S6 kinase and participates in the inactivation of 4E-BP1 (5) . mTOR plays a key role in homeostasis and cell growth, and phospho mTOR may be abnormally regulated in tumors. mTOR is a potential target for anti-cancer therapy (6) .
Product Name Alternative
Serine/threonine-protein kinase mTOR, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, FRAP, FRAP1, FRAP2, RAFT1, RA
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser2448 of human phospho mTOR
Clonality
Monoclonal
Clone
MTORS2448-E11
Applications
FACS
Format
Purified
Components
1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage Conditions
Store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
1μg/mL - 0.001μg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information. (0.5mg/ml, more than 200 western blots)
Isotype
Rabbit IgG1k
Conjugate
Unconjugated

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