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Polyclonal Antibody to TRBP

CAT: 0793-11-13003-25Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0793-11-13003-25Size:25 µg
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Description
TRBP, also known as TARBP2 (TAR (HIV-1) RNA binding protein 2) is a contributory agent of acquired immunodeficiency syndrome (AIDS) . TRBP binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. It also plays a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 and promotes translation of TAR-containing RNAs independently of EIF2AK2/PKR. Diseases associated with TARBP2 include acquired immunodeficiency syndrome. TARBP2 is highly expressed in adipose tissue, adrenal cortex, adrenal gland, amniotic fluid and amygdala. TRBP exists in two isoforms whereas alternate splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.
Product Name Alternative
TARBP2||TRBP
Gene Name
TARBP2
Gene ID
6895
UniProt
Q15633
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant TRBP protein (amino acids 150-366) was used as the immunogen for this antibody.
Target Antigen
TRBP
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 6-7μg/mL
Isotype
Rabbit IgG

UniProtKB · Q15633

RISC-loading complex subunit TARBP2

TRBP2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15633
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TARBP2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q12878, Q8WY32, Q8WY33, Q9BRY2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usage

Cellular component

CytoplasmNucleus

PTM

Phosphoprotein

Domain

Repeat

Molecular function

RNA-binding

Biological process

RNA-mediated gene silencingTranslation regulation

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