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Polyclonal Antibody to KLF4

CAT: 0793-11-12004-25Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0793-11-12004-25Size:25 µg
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Description
Kruppel like factor 4 (KLF4) which are also called as gun enriched kruppel like factors (GKLF) is a member of SP/KLF family of zinc transcription factors that are involved in numerous important cellular processes, such as, proliferation, inflammation, apoptosis and somatic cell reprogramming. The Kruppel zinc finger transcription factor was initially identified in Drosophila as a segmented gene. This protein is found to inhibit cell proliferation by functioning as a cell cycle checkpoint protein that leads to activation of transcription of the cyclin-dependent kinase inhibitor. Clinically KLF4 plays a role in the pathogenesis of esophageal cancer and malaria. It has five isoform that are produced by alternate splicing. Expression of KLF4 is highly enriched in the post replicative epithelial cells of the intestine, skin and thymus.
Product Name Alternative
KLF4||EZF||GKLF
Gene Name
KLF4
Gene ID
9314
UniProt
O43474
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant KLF4 protein (amino acids 1-300) was used as the immunogen for this antibody.
Target Antigen
KLF4/GKLF
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL
Isotype
Rabbit IgG

UniProtKB · O43474

Krueppel-like factor 4

KLF4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43474
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KLF4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R8S4, B3KT79, L0R3I6, L0R4N5, P78338, Q5T3J8, Q5T3J9, Q8N717, Q9UNP3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

Biological process

TranscriptionTranscription regulation

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