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Polyclonal Antibody to SOX2

CAT: 0793-11-7554-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0793-11-7554-100Size:100 µg
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Description
SOX2 is a member of the SRY-related HMG-box (SOX) transcription factor family with a set of well-established and diverse roles in stem cell potency and maintenance, embryonic development and cancer. It regulates extensive and often divergent transcriptional networks across different cell types. SOX2 is best known as a core pluripotency factor, maintaining the undifferentiated phenotype of pluripotent stem cells, and is closely co-regulated alongside core pluripotency factors OCT4 and NANOG in undifferentiated ESCs (Embryonic Stem Cells), ECCs (Embryonal Carcinoma Cells) and iPSCs (Induced Pluripotent Stem Cells) . Loss of SOX2 expression in these cell lines triggers their differentiation. More recently, SOX2 has been identified as a crucial player in the maintenance and differentiation of adult stem cells such as in neural stem cells. Moreover, high expression levels of SOX2 correlate with tumor progression or poor prognosis of multiple cancers. In contrast, the tumor-suppressive role of SOX2 has been reported in gastric cancer and squamous cell lung cancer.
Product Name Alternative
SOX2
Gene Name
SOX2
Gene ID
6657
UniProt
P48431
Host
Rabbit
Reactivity
Human
Immunogen
A full length recombinant Sox2 protein was used as the immunogen for this antibody.
Target Antigen
SOX2
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2 μg/mL
Isotype
Rabbit IgG

UniProtKB · P48431

Transcription factor SOX-2

SOX2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P48431
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SOX2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q14537
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Cellular component

CytoplasmNucleus

Disease

Disease variantMicrophthalmia

PTM

Isopeptide bondMethylationPhosphoproteinUbl conjugation

Biological process

TranscriptionTranscription regulation

Related Products

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36-3166-100Anti-SOX2 (Embryonic Stem CellMarker) Monoclonal Antibody (Clone: SOX2/1791)
36-3166-20Anti-SOX2 (Embryonic Stem CellMarker) Monoclonal Antibody (Clone: SOX2/1791)
10-8015-25Monoclonal Antibody to SOX2 (Clone: ABM46A5)
36-3171-20Anti-SOX2 (Embryonic Stem Cell Marker) Monoclonal Antibody (Clone: SOX2/3811R)
36-3167-20Anti-SOX2 (Embryonic Stem Cell Marker) Monoclonal Antibody (Clone: SOX2/1792)
36-3171-100Anti-SOX2 (Embryonic Stem Cell Marker) Monoclonal Antibody (Clone: SOX2/3811R)
36-3170-20Anti-SOX2 (Embryonic Stem Cell Marker) Monoclonal Antibody (Clone: SOX2/3169R)
10-8015-100Monoclonal Antibody to SOX2 (Clone: ABM46A5)
36-3170-100Anti-SOX2 (Embryonic Stem Cell Marker) Monoclonal Antibody (Clone: SOX2/3169R)
36-3167-100Anti-SOX2 (Embryonic Stem Cell Marker) Monoclonal Antibody (Clone: SOX2/1792)

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MBS125852-01SOX2 Polyclonal Antibody
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