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Polyclonal Antibody to p65

CAT: 0793-11-6002-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0793-11-6002-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P65 is a subunit of the NF-KappaB, a second messenger, which activates the transcription of a number of genes in multiple tissues. It is a ubiquitously expressed protein that can bind to the kB site alone. In addition, p65 is shown to be the subunit responsible for providing transcriptional activity of the NF-kB (p65-p50) heterodimeric complex. The inhibitory effect of I-KappaB upon NF-KappaB in the cytoplasm is exerted primarily through the interaction with P65. It shows a weak DNA binding site, which could contribute directly to DNA binding in the NF-KappaB complex.
Product Name Alternative
RELA||NFKB3
Gene Name
RELA
Gene ID
5970
UniProt
Q04206
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant p65 protein (amino acids 1-200) was used as the immunogen for this antibody.
Target Antigen
P65
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL
Isotype
Rabbit IgG

UniProtKB · Q04206

Transcription factor p65

TF65_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q04206
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RELA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6GTV1, Q6SLK1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

CytoplasmNucleus

Disease

Disease variant

Biological process

Host-virus interactionTranscriptionTranscription regulation

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