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Polyclonal Antibody to DUBA

CAT: 0793-11-3014-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0793-11-3014-100Size:100 µg
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Description
DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.
Product Name Alternative
OTUD5
Gene Name
OTUD5
Gene ID
55593
UniProt
Q96G74
Host
Rabbit
Reactivity
Mouse, Human
Immunogen
A partial length recombinant DUBA protein (amino acids 300-520) was used as the immunogen for this antibody.
Target Antigen
DUBA
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL
Isotype
Rabbit IgG

UniProtKB · Q96G74

OTU domain-containing protein 5

OTUD5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96G74
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
OTUD5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.19.12
Processing
—
Secondary accessions
B4DGG7, G5E9D7, Q4KMN9, Q8N6T5, Q9H650, Q9H9U0, Q9NT65
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variantIntellectual disability

Molecular function

HydrolaseProteaseThiol protease

Cellular component

Nucleus

PTM

Phosphoprotein

Biological process

Ubl conjugation pathway

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Alternative Products

CatalogName
MBS668141-01DUBA Polyclonal Antibody
MBS9236317-01OTUD5/DUBA Polyclonal Antibody
GTR17707624-01OTUD5/DUBA Rabbit Polyclonal Antibody
TMAB-09833-01Anti-OTUD5/DUBA Polyclonal Antibody
APG00555GPolyclonal DUBA Antibody (internal region)
GTR17716474OTUD5/DUBA Rabbit Polyclonal Antibody (HRP)
bs-17566R-HRPOTUD5/DUBA Polyclonal Antibody, HRP Conjugated
bs-17566R-Cy5OTUD5/DUBA Polyclonal Antibody, Cy5 Conjugated
bs-17566R-Cy3OTUD5/DUBA Polyclonal Antibody, Cy3 Conjugated
bs-17566R-APCOTUD5/DUBA Polyclonal Antibody, APC Conjugated

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