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MSH5 rabbit pAb

CAT: 0855-ES14702-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES14702-01Size:50 µL
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Background
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Description
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011],
UniProt
O43196
Swiss Prot
O43196
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human MSH5 AA range: 13-63
Target
MSH5
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Synaptonemal complex, mismatch repair complex
Gene ID (Human)
4439

UniProtKB · O43196

MutS protein homolog 5

MSH5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43196
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MSH5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hMSH5
EC number
—
Processing
—
Secondary accessions
B0V033, B0V034, O60586, Q5BLU9, Q5SSR1, Q8IW44, Q9BQC7
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Disease

Disease variantPremature ovarian failure

Biological process

DNA damageDNA repairMeiosis

Molecular function

DNA-binding

Technical term

Proteomics identificationReference proteome

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