Products for Research Use Only
RegisterLogin

Tambiciclib

CAT: 0127-OR1102210-03Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0127-OR1102210-03Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2247481-08-7
MDL Number
MFCD35444586
Purity
95%
Smiles
COC[C@@H] (C) N[C@@H] (CC1) CC[C@H]1NC2=CC (C3=CSC (NCC4 (CCOCC4) C#N) =N3) =C (Cl) C=N2

Chemical Information

Tambiciclib

Tambiciclib is a selective inhibitor of the serine/threonine cyclin-dependent kinase 9 (CDK9), the catalytic subunit of the RNA polymerase II (RNA Pol II) elongation factor positive transcription elongation factor b (PTEF-b; PTEFb), with potential antineoplastic activity. Upon administration, tambiciclib targets, binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II, leading to the inhibition of gene transcription of various anti-apoptotic proteins. This induces cell cycle arrest and apoptosis and prevents tumor cell proliferation. CDK9 regulates elongation of transcription through phosphorylation of RNA Pol II at serine 2 (p-Ser2-RNAPII). It is upregulated in various tumor cell types and plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.

CAS Number2247481-08-7
PubChem CID141725841
IUPAC Name4-[[[4-[5-chloro-2-[[4-[[(2R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]-4-pyridinyl]-1,3-thiazol-2-yl]amino]methyl]oxane-4-carbonitrile
Molecular FormulaC25H35ClN6O2S
Molecular Weight519.1
XLogP4.4
Topological Polar Surface Area132
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Heavy Atom Count35
Formal Charge0
Complexity697
SMILES
C[C@H](COC)NC1CCC(CC1)NC2=NC=C(C(=C2)C3=CSC(=N3)NCC4(CCOCC4)C#N)Cl
InChI
InChI=1S/C25H35ClN6O2S/c1-17(13-33-2)30-18-3-5-19(6-4-18)31-23-11-20(21(26)12-28-23)22-14-35-24(32-22)29-16-25(15-27)7-9-34-10-8-25/h11-12,14,17-19,30H,3-10,13,16H2,1-2H3,(H,28,31)(H,29,32)/t17-,18?,19?/m1/s1
InChIKey
PGVNLOUNSPQGJP-LMDPOFIKSA-N
Chemical Structure
2D Structure
2D structure of Tambiciclib
CAS: 2247481-08-7
CID: 141725841
Formula: C25H35ClN6O2S
MW: 519.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight519.1
XLogP34.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Exact Mass518.2230732
Monoisotopic Mass518.2230732
Topological Polar Surface Area132 Ų
Heavy Atom Count35
Formal Charge0
Complexity697
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-X0009-01Tambiciclib
HY-X0009A-01Tambiciclib (dimaleate)

Popular Products