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Toladryl (Standard)

CAT: 0804-HY-138110RSize: 1 EachDry Ice: NoHazardous: No
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Description
Toladryl (Standard) is the analytical standard of Toladryl. This product is intended for research and analytical applications. Toladryl is a derivative of Diphenhydramine , capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases[1].
CAS Number
19804-27-4
Product Name Alternative
4-Methyldiphenhydramine (Standard)
UNSPSC
12352005
Target
Endogenous Metabolite; Histamine Receptor; iGluR; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/toladryl-standard.html
Smiles
CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C)C=C2
Molecular Formula
C18H23NO
Molecular Weight
269.38
References & Citations
[1]McGavack T H, et al. Newer antihistaminics: III. Some pharmacologic and therapeutic effects of β- (P-methylbenzhydryloxy) -ethyldimethylamine hydrochloride, a derivative of diphenhydramine hydrochloride[J]. Journal of Allergy, 1950, 21 (4) : 353-370.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

4-Methyldiphenhydramine
CAS Number19804-27-4
PubChem CID19935
IUPAC NameN,N-dimethyl-2-[(4-methylphenyl)-phenylmethoxy]ethanamine
Molecular FormulaC18H23NO
Molecular Weight269.4
XLogP3.6
Topological Polar Surface Area12.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Heavy Atom Count20
Formal Charge0
Complexity252
SMILES
CC1=CC=C(C=C1)C(C2=CC=CC=C2)OCCN(C)C
InChI
InChI=1S/C18H23NO/c1-15-9-11-17(12-10-15)18(20-14-13-19(2)3)16-7-5-4-6-8-16/h4-12,18H,13-14H2,1-3H3
InChIKey
PJUYQWIDNIAHIZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-Methyldiphenhydramine
CAS: 19804-27-4
CID: 19935
Formula: C18H23NO
MW: 269.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight269.4
XLogP33.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass269.177964357
Monoisotopic Mass269.177964357
Topological Polar Surface Area12.5 Ų
Heavy Atom Count20
Formal Charge0
Complexity252
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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