Toladryl (Standard)

Toladryl (Standard)

• CAS Number: 19804-27-4
• UNSPSC Description: Toladryl (Standard) is the analytical standard of Toladryl. This product is intended for research and analytical applications. Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases[1].
• Target Antigen: Endogenous Metabolite; Histamine Receptor; iGluR
• Type: Reference Standards
• Related Pathways: GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/toladryl-standard.html
• Smiles: CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C)C=C2
• Molecular Weight: 269.38
• References & Citations: [1]McGavack T H, et al. Newer antihistaminics: III. Some pharmacologic and therapeutic effects of β-(P-methylbenzhydryloxy)-ethyldimethylamine hydrochloride, a derivative of diphenhydramine hydrochloride[J]. Journal of Allergy, 1950, 21(4): 353-370.
• Shipping Conditions: Room temperature