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Crobenetine

CAT: 0804-HY-16923-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16923-01Size:1 mg
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Description
Crobenetine (BIII-890), a benzomorphan derivative, is a potent, selective, and highly use-dependent Na+ channel blocker. Crobenetine displaces [3H]BTX from site 2 of the Na+ channel (IC50=49 nM) in rat brain synaptosomes, yet exhibits only low binding affinity for other receptors and ion channels. Crobenetine protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents[1].
CAS Number
221019-25-6
Product Name Alternative
BIII-890; BIII-890 CL (free acid)
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/crobenetine.html
Smiles
OC1=C2C([C@]3(C)CCN(C[C@@H](OCC4=CC=CC=C4)C)[C@](C3(C)C)([H])C2)=CC=C1
Molecular Formula
C25H33NO2
Molecular Weight
379.54
References & Citations
[1]A J Carter, et al. Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. Proc Natl Acad Sci U S A. 2000 Apr 25;97 (9) :4944-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
T69795-01Crobenetine
MBS5776807Crobenetine hydrochloride

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