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Denibulin

CAT: 0804-HY-14919Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14919Size:1 Each
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Description
Denibulin, a novel vascular-disrupting agent, inhibits microtubule assembly reversibly, disrupting tumor vascular endothelial cell cytoskeletons. Denibulin demonstrated tolerability and potential anti-vascular effects, warranting further investigation in cancer therapy[1].
CAS Number
284019-34-7
Product Name Alternative
MN-029 (free base)
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/denibulin.html
Smiles
O=C(OC)NC1=NC2=CC(SC3=CC=C(NC([C@@H](N)C)=O)C=C3)=CC=C2N1
Molecular Formula
C18H19N5O3S
Molecular Weight
385.44
References & Citations
[1]A phase I study of MN-029 (denibulin), a novel vascular-disrupting agent, in patients with advanced solid tumors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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