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Denibulin HCl

CAT: 0931-T68708-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68708-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
779356-64-8
Target
Others, Microtubule Associated
Related Pathways
Cytoskeletal Signaling, Others
Bioactivity
Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy.
Smiles
Cl.COC(=O)Nc1nc2ccc(Sc3ccc(NC(=O)[C@H](C)N)cc3)cc2[nH]1
Molecular Formula
C18H20ClN5O3S
Molecular Weight
421.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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