ETP-45658

• Description:

  ETP-45658 is a potent PI3K inhibitor, with IC50s of 22.0 nM, 39.8 nM, 129.0 nM and 717.3 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. ETP-45658 also can inhibit DNA-PK (IC50=70.6 nM) and mTOR (IC50=152.0 nM) . ETP-45658 can be used for the research of cancer[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  DNA-PK; mTOR; PI3K

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/etp-45658.html

• Concentration:

  10mM

• Purity:

  98.97

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  CN1C2=NC (C3=CC (O) =CC=C3) =NC (N4CCOCC4) =C2C=N1

• Molecular Formula:

  C16H17N5O2

• Molecular Weight:

  311.34

• Precautions:

  H315, H319

• References & Citations:

  [1]Link W, et, al. Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases. J Biol Chem. 2009 Oct 9;284 (41) :28392-28400.|[2]Hill R, et, al. A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. Breast Cancer Res. 2014 Dec 9;16 (6) :482.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

• CAS Number:

  1198357-79-7