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ETP-45835

CAT: 0804-HY-W846144Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W846144Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ETP-45835 is slective and potent MNK inhibitor with IC50s of 575 nM and 646 nM for MNK1 and MNK2, respectively. ETP-45835 shows little activity against 24 other kinases. ETP-45835 inhibits eIF4E Ser209 phosphorylation in cells, and has anticancer effects[1].
CAS Number
794510-70-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/etp-45835.html
Smiles
N=1C=CC(=CC1)C2=NNC(=C2)C3CCNCC3
Molecular Formula
C13H16N4
Molecular Weight
228.29
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Julen Oyarzabal, et al. Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J Med Chem. 2010 Sep 23;53 (18) :6618-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MNK1; MNK2

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