Products for Research Use Only
RegisterLogin

Leptin Human

CAT: 0127-BI12295Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0127-BI12295Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
177404-21-6
MDL Number
MFCD01094205

Chemical Information

Leptin

Although leptin is a circulating signal that reduces appetite, in general, obese people have an unusually high circulating concentration of leptin. These people are said to be resistant to the effects of leptin, in much the same way that people with type 2 diabetes are resistant to the effects of insulin. Thus, obesity develops when people take in more energy than they use over a prolonged period of time, and this excess food intake is not driven by hunger signals, occurring in spite of the anti-appetite signals from circulating leptin. The high sustained concentrations of leptin from the enlarged fat stores result in the cells that respond to leptin becoming desensitized.

CAS Number177404-21-6
PubChem CID157010069
IUPAC Name(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-1-hydroxy-4-methylpentylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxyethylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-4-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-3-carboxy-1-[(2S)-1-[(2S)-1-[(2S)-2-[N-[2-[(1R)-1-carboxy-2-sulfanylethyl]imino-2-hydroxyethyl]-C-hydroxycarbonimidoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]imino-1-hydroxy-4-methylpentan-2-yl]imino-1-hydroxypropan-2-yl]imino-1-hydroxy-4-methylpentan-2-yl]imino-1,5-dihydroxy-5-iminopentan-2-yl]imino-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl]imino-1-hydroxy-4-methylpentan-2-yl]imino-1-hydroxy-4-methylsulfanylbutan-2-yl]imino-4-hydroxybutanoic acid
Molecular FormulaC87H138N22O28S2
Molecular Weight2004.3
XLogP4.4
Topological Polar Surface Area894
Hydrogen Bond Donor Count30
Hydrogen Bond Acceptor Count50
Rotatable Bond Count65
Heavy Atom Count139
Formal Charge0
Complexity4540
SMILES
CC(C)C[C@@H](C(=N[C@@H](CCC(=N)O)C(=NCC(=N[C@@H](CO)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CC(=O)O)C(=N[C@@H](CCSC)C(=N[C@@H](CC(C)C)C(=N[C@@H](CC1=CNC2=CC=CC=C21)C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CC(C)C)C(=N[C@@H](CC(=O)O)C(=N[C@@H](CC(C)C)C(=N[C@@H](CO)C(=O)N3CCC[C@H]3C(=NCC(=N[C@@H](CS)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N
InChI
InChI=1S/C87H138N22O28S2/c1-41(2)27-48(88)72(121)97-50(18-21-65(89)112)73(122)93-36-68(115)95-61(38-110)84(133)104-54(28-42(3)4)77(126)98-52(20-23-67(91)114)75(124)106-59(33-70(117)118)82(131)100-53(24-26-139-11)76(125)102-55(29-43(5)6)78(127)105-58(32-46-35-92-49-16-13-12-15-47(46)49)81(130)99-51(19-22-66(90)113)74(123)101-56(30-44(7)8)79(128)107-60(34-71(119)120)83(132)103-57(31-45(9)10)80(129)108-62(39-111)86(135)109-25-14-17-64(109)85(134)94-37-69(116)96-63(40-138)87(136)137/h12-13,15-16,35,41-45,48,50-64,92,110-111,138H,14,17-34,36-40,88H2,1-11H3,(H2,89,112)(H2,90,113)(H2,91,114)(H,93,122)(H,94,134)(H,95,115)(H,96,116)(H,97,121)(H,98,126)(H,99,130)(H,100,131)(H,101,123)(H,102,125)(H,103,132)(H,104,133)(H,105,127)(H,106,124)(H,107,128)(H,108,129)(H,117,118)(H,119,120)(H,136,137)/t48-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1
InChIKey
NRYBAZVQPHGZNS-ZSOCWYAHSA-N
Chemical Structure
2D Structure
2D structure of Leptin
CAS: 177404-21-6
CID: 157010069
Formula: C87H138N22O28S2
MW: 2004.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight2004.3
XLogP34.4
Hydrogen Bond Donor Count30
Hydrogen Bond Acceptor Count50
Rotatable Bond Count65
Exact Mass2002.9492342
Monoisotopic Mass2002.9492342
Topological Polar Surface Area894 Ų
Heavy Atom Count139
Formal Charge0
Complexity4540
Isotope Atom Count0
Defined Atom Stereocenter Count16
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
BITP1985-01Mouse Anti Human Leptin
BITP1342Human myeloperoxidase
BITP1362-01Human Urokinase
BINY107Granulysin, human
BIBA1029Amylin (human)
BINY101Granzyme A, human
BITP1545-01Human Eptifibatide
BIBA1020Adrenomedullin (human)
BITP1489-01Recombinant Human CD14
BITP1419-01Recombinant Human STAT3

Alternative Products

CatalogName
PT_41403-01Human Leptin (Leptin Human)
OPPA01996-200UGLeptin Human - Human Leptin Protein
PT_41389-01Leptin Human Recombinant (Leptin Human)
EK710057Human Leptin (Leptin) Elisa Kit
MBS691942-01Human Leptin
Z02962-5Leptin, Human
PR27097-BLeptin-Human
OM301117-01Leptin Human
MO15019Leptin (Human)

Popular Products