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Degarelix-d7

CAT: 0804-HY-16168AS-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16168AS-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Degarelix-d7 (FE 200486-d7 free base) is deuterium labeled Degarelix. Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
Product Name Alternative
FE 200486-d7 (free base)
UNSPSC
12352005
Target
GnRH Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Solubility
10 mM in DMSO
Smiles
NC(NC(C=C1)=CC=C1C[C@@H](NC([C@@H](NC([C@H](CO)NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)CC4=CC=C(C=C4)Cl)=O)CC5=CN=CC=C5)=O)=O)CC6=CC=C(C=C6)NC([C@@H]7CC(NC(N7)=O)=O)=O)=O)C(N[C@@H](CC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])C(N[C@@H](CCCCNC(C)C)C(N8[C@@H](CCC8)C(N[C@H](C)C(N)=O)=O)=O)=O)=O)=O
Molecular Formula
C82H96D7ClN18O16
Molecular Weight
1639.30
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Broqua P, et al. Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormoneantagonist: degarelix. J Pharmacol Exp Ther. 2002 Apr;301 (1) :95-102.|[3]Rick FG, et al. An update on the use of degarelix in the treatment of advanced hormone-dependent prostate cancer. Onco Targets Ther. 2013 Apr 16;6:391-402.|[4]Sakai M, et al. In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonistdegarelix on human prostate cell growth. PLoS One. 2015 Mar 26;10 (3) :e0120670.|[5]Sonesson A, et al. Metabolite profiles of degarelix, a new gonadotropin-releasing hormone receptor antagonist, in rat, dog, and monkey. Drug Metab Dispos. 2011 Oct;39 (10) :1895-903.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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