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BACE1/ASP2 Protein (Human)

CAT: 1543-P513406Size: 100 µgDry Ice: NoHazardous: No
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CAT#:1543-P513406Size:100 µg
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Abbreviation
BACE1/ASP2
Synonyms
ASP2, BACE, HSPC104
UniProt
P56817
Host
HEK 293
Applications
Enzyme
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Measured by its ability to cleave a fluorescent peptide substrate Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys (Dpn) -Arg-Arg-NH2 (Catalog# ES004, R&D Systems) . Cleavage of ES004 can be measured using excitation and emission wavelength of 320 and 405 nm, respectively. The specific activity is > 3. 5 pmoles/min/μg.
Function
Met 1-Thr 457
Molecular Weight
49.0 kDa
Species
Human

UniProtKB · P56817

Beta-secretase 1

BACE1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P56817
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BACE1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.23.46
Processing
Precursor
Secondary accessions
A0M8W7, B0YIU9, E9PE65, H7BXJ9, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugationZymogen

Coding sequence diversity

Alternative splicing

Molecular function

Aspartyl proteaseHydrolaseProtease

Cellular component

Cell membraneCell projectionCytoplasmic vesicleEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembrane

Domain

SignalTransmembraneTransmembrane helix

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PKSH031900Recombinant Human BACE1/ASP2 Protein
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ARP7664-01Recombinant Human BACE1 / ASP2 Protein (Fc tag)
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PKSH031902Recombinant Human BACE1/ASP2 Protein (Fc Tag)
PKSH031901Recombinant Human BACE1/ASP2 Protein (His Tag)
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