Zaltoprofen

Zaltoprofen

• CAS Number: 74711-43-6
• UNSPSC Description: Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].
• Target Antigen: COX
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Neuroscience-Neuromodulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/zaltoprofen.html
• Purity: 99.28
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: CC(C1=CC=C(SC2=C3C=CC=C2)C(CC3=O)=C1)C(O)=O
• Molecular Weight: 298.36
• References & Citations: [1]Kawai S, et, al. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur J Pharmacol. 1998 Apr 17;347(1):87-94.|[2]Hirate K, et, al. Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Neurosci Res. 2006 Apr;54(4):288-94.|[3]Kameyama T, et, al. Analgesic and antiinflammatory effects of 2-(10,11-dihydro-10-oxo-dibenzo[b,f]thiepin-2-yl)propionic acid in rat and mouse. Arzneimittelforschung. 1987 Jan;37(1):19-26.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched