Zaltoprofen

• Description:

  Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].

• Product Name Alternative:

  CN100

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  COX

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/zaltoprofen.html

• Purity:

  99.28

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  CC (C1=CC=C (SC2=C3C=CC=C2) C (CC3=O) =C1) C (O) =O

• Molecular Formula:

  C17H14O3S

• Molecular Weight:

  298.36

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kawai S, et, al. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur J Pharmacol. 1998 Apr 17;347 (1) :87-94.|[2]Hirate K, et, al. Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Neurosci Res. 2006 Apr;54 (4) :288-94.|[3]Kameyama T, et, al. Analgesic and antiinflammatory effects of 2- (10,11-dihydro-10-oxo-dibenzo[b, f]thiepin-2-yl) propionic acid in rat and mouse. Arzneimittelforschung. 1987 Jan;37 (1) :19-26.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  COX-1; COX-2

• CAS Number:

  74711-43-6