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CHIR-124

CAT: 0026-B3069-1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0026-B3069-1Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHIR-124 is a quinolone-based inhibitor of Checkpoint kinase-1 (Chk1). It potently and selectively inhibits Chk1 in vitro with an IC₅₀ of 0.3 nM. It interacts synergistically with topoisomerase poisons (e.g., camptothecin) in inhibiting the growth of several p53-mutant solid tumor cell lines. CHIR-124 potentiates the growth inhibitory effects of irinotecan by abrogating the G2-M checkpoint and increasing tumor apoptosis in a breast cancer xenograft model.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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444297-01CHIR 124
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