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Anti-MKRN2 Antibody

CAT: 0519-M10562-50ulSize: 50 µLDry Ice: NoHazardous: No
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CAT#:0519-M10562-50ulSize:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Description
Boster Bio Anti-MKRN2 Antibody (Catalog # M10562) . Tested in WB, Flow Cytometry, IHC-P, IF application (s) . This antibody reacts with Human.
Synonyms
Probable E3 ubiquitin-protein ligase makorin-2, 632-, RING finger protein 62, MKRN2, RNF62
Gene Name
MKRN2
UniProt
Q9H000
Host
Mouse
Reactivity
Human
Immunogen
This MKRN2 antibody is generated from a mouse immunized with recombinant protein.
Clonality
Monoclonal
Clone
Clone: 1556CT631.230.55.49
Tissue Specificity
Expressed in sperm, with significantly reduced expression in sperm of patients with oligoasthenoteratozoospermia (at protein level) (PubMed:28008940) . Widely expressed with expression in testis, ovary, small intestine, colon, peripheral blood leukocytes, fetal liver, bone marrow, thymus, lymph node and spleen (PubMed:11597136) .
Applications
WB, Flow Cytometry, IHC-P, IF
Field of Research
Cell Biology, Neuroscience
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity) . Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity) . Plays a role in the regulation of spermiation and in male fertility (By similarity) .
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
46940 Da
Subcellular Location
Cytoplasm {ECO:0000250|UniProtKB:Q9ERV1}. Nucleus {ECO:0000250|UniProtKB:Q9ERV1}
Isotype
IgG1, k
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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